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Reaktivitet, Human,Rat,Mouse. Värd, Rabbit. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants Gene expression analyses showed that Pam2 treatment resulted in increased of inflammation- induced new bone formation may be due to enhanced gp130 In Paper IV, the impact of various gp130 signalling cytokines on endothelial cells revealed differences and similarities in intracellular signalling, gene expression av A Krona · 2006 · Citerat av 1 — Gene expression studies in human astrocytoma, with emphasis on oncostatin M induced effects. Please use this identifier to cite or link to this item: http://hdl.handle Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130 Marwa Malki Absence of GP130 cytokine receptor signaling causes extended Novel genetic and epigenetic factors of importance for inter-individual differences in drug Uppsats: Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130.
Enrichment of STAT3 regulation and gp130-ligands in activated fibroblasts and macrophages led us to reason that gp130 blockade might rescue the activated program. Supplementary Tables 8 (gene Enhancement of gp130/STAT3 activity by SPRC in Dox-induced cardiomyocytes. To confirm the facilitating effect of SPRC on gp130/STAT3 activation, a Dox-induced cardiac injury model was established Fig. S3. Gene signature for Wnt and gp130-Jak-Stat3 signaling coexists in human CRCs. Fig. S4. Xenograft growth is suppressed by partial inhibition of the gp130-Jak-Stat3 pathway without affecting Stat1. Fig. S5. Stimulation of gp130-Jak-Stat3 signaling does not affect aberrant Wnt–β-catenin signaling in the SW480 human CRC cell line.
Fig. S3. Gene signature for Wnt and gp130-Jak-Stat3 signaling coexists in human CRCs. Fig. S4. Xenograft growth is suppressed by partial inhibition of the gp130-Jak-Stat3 pathway without affecting Stat1.
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CNTF-CNTFR- gp130 -LIFR complex Gene Set Three SNPs in the gp130 gene and two SNPs in the LIFR gene were analyzed using real-time PCR. One significant difference and a tendency to difference were detected in the gp130 gene for women with unexplained infertility. There were no differences in the LIFR gene variations.
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HEK293T cells were used for the co-transfection experiments as they can be better transfected than liver-derived cells, thereby providing a smaller variability between the biological replicates. Detection of gp130 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse CD3 PE-conjugated Monoclonal Antibody (Catalog # FAB4841P) and either (A) Rat Anti-Mouse gp130 Monoclonal Antibody (Catalog # MAB4681) or (B) Rat IgG2A Isotype Control (Catalog # MAB006 ) followed by Allophycocyanin-conjugated Anti-Rat IgG Secondary Antibody (Catalog # F0113 ).
Enrichment of STAT3 regulation and gp130-ligands in activated fibroblasts and macrophages led us to reason that gp130 blockade might rescue the activated program. Supplementary Tables 8 (gene
Enhancement of gp130/STAT3 activity by SPRC in Dox-induced cardiomyocytes. To confirm the facilitating effect of SPRC on gp130/STAT3 activation, a Dox-induced cardiac injury model was established
Fig. S3. Gene signature for Wnt and gp130-Jak-Stat3 signaling coexists in human CRCs. Fig. S4. Xenograft growth is suppressed by partial inhibition of the gp130-Jak-Stat3 pathway without affecting Stat1.
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27 antibodies to GP130 and validated for use in 8 applications (Immunohistochemistry, Western Blot, Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Immunofluorescence, ELISA, Neutralization) 2018-03-14 · Dictyostelium discoideum gp130 gene and function Chia, et al. Manuscript E04-06-0483R p. 3 Abstract Glycoprotein gp130, found on the plasma membrane of Dictyostelium discoideum amoebae, was postulated previously to play a role in phagocytosis. The gene for gp130 was cloned and when translated, yielded a 768 amino acid preproprotein of 85.3 kDa. It genes co-occuring with the biological term gp130 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
Cell . Gene .
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Anti-GP130 Rabbit Polyclonal Antibody Alexa Fluor® 488
Fig. S6. 2019-05-17 · If gp130 expression is lower than IL-6Rα expression, gp130 acts as a bottleneck for trans- and classic signalling, hence, trans-signalling cannot surpass classic signalling. In line with this hypothesis HepG2 cells, where trans-signalling is stronger than classic signalling, express eight times more gp130 than IL-6Rα (Fig. 2 d). home > human > gp130 gene knockdown | 1 product cited in the literature; 10 total from 3 suppliers Your Filters. product. gp130 siRNA (h) Santa Cruz Biotechnology The role of gp130/Stat3 in promoting the expression of these genes in OVCAR-8 cells was confirmed by silencing of gp130 (Supplementary Fig. S4A) and Stat3 (Supplementary Fig. S4B).
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GP130 signaling is required for tumor cell survival in diverse forms of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations. In the present study, we investigated the possibility that activation of gp130 initiates activation of the cytoprotective genes in cardiac myocytes.
Learn more about gp130/IL6ST gene information & reagent We found that gene therapy with AAV9-gp130 ACT, encoding a sustainably activated form of gp130, could improve heart regeneration effectively with cardiomyocyte proliferation after MI in adult mice.